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Forschung und Dienstleistung

Dienstleistungen am EMZ

mehr über die Dienstleistungsmöglichkeiten am EMZ erfahren Sie hier!

Aktuell: Bitte beachten Sie die neue Gebührenordnung des EMZ gültig ab 01.08.2017!


Forschungs- und Kooperationsprojekte am EMZ

Forschungsprojekte

  • Bau und Entwicklung der Vogellunge
  • Struktur und Funktion multiziliärer Zellen
  • Neue Verfahren der korrelativen Mikroskopie

Darüberhinaus werden zahlreiche Kooperationsprojekte durchgeführt. Für weitere Informationen wenden Sie sich bitte an PD Dr. Marcus Frank.

marcus.frank{bei}med.uni-rostock.de


Aktuelle Veröffentlichungen

Osten J, Milkereit B, Reich M, Yang B, Springer A, Nowak K, Kessler O (2020) Development of Precipitation Hardening Parameters for High Strength Alloy AA 7068. Materials 2020, 13, 918.

Jandl NM, Rolvien T, Gätjen D, Jonitz-Heincke A, Springer A, Krenn V, Bader R, Rüther W (2019) Recurrent arthrocele and sterile sinus tract formation due to ceramic wear as a differential diagnosis of periprosthetic joint infection. A case report. Acta Orthopaedica. 90(5):501-504. 2019, DOI: 10.1080/17453674.2019.1616997

Schnell G, Jagow C, Springer A, Frank M, Seitz H (2019) Time-Dependent Anisotropic Wetting Behavior of Deterministic Structures of Different Strut Widths on Ti6Al4V. Metals 9, 938

Kovalchuk V, Voronkina A, Binnewerg B, Schubert M, Muzychka L, Wysokowski M, Tsurkan MV, Bechmann N, Petrenko I, Fursov A, Martinovic R, Ivanenko VN, Fromont J, Smolii OB, Joseph Y, Giovine M, Erpenbeck D, Gelinsky M, Springer A, Guan K, Bornstein SR, Ehrlich H (2019) Naturally Drug-Loaded Chitin: Isolation and Applications. Mar. Drugs. 17(10), 574

Rustgi S, Springer A, Kang C, von Wettstein D, Reinbothe C, Reinbothe S, Pollmann S (2019) Allene Oxide Synthase and Hydroperoxide Lyase, Two Non-Canonical Cytochrome P450s in Arabidopsis thaliana and Their Different Roles in Plant Defense. Int. J. Mol. Sci. 20(12), 3064. doi:10.3390/ijms20123064

Handoko CT, Moustakas NG, Peppel T, Springer A, Oropeza FE, Huda A, Bustan MD, Yudono B, Gulo F, Strunk J (2019) Characterization and Effect of Ag(0) vs. Ag(I) Species and Their Localized Plasmon Resonance on Photochemically Inactive TiO2. Catalysts. 9(4):323

Wetegrove M, Witte K, Bodnar W, Pfahl DE, Springer A, Schell N, Westphal F, Burkel E (2019) Formation of maghemite nanostructures in polyol: tuning the particle size via the precursor stoichiometry. CrystEngCom. 21, 1956-1966. doi: 10.1039/c8ce02115e, 2019

Adamus A, Peer K, Ali I, Lisec J, Zalodun A, Frank M, Seitz G, Engel N (2019) Berberis orthobotrys - A promising herbal anti-tumorigenic candidate for the treatment of pediatric alveolar rhabdomyosarcoma. J Ethnopharmacol. 229:262-271. doi: 10.1016/j.jep.2018.10.002

Hagemann M, Möke F, Springer A, Westermann L, Frank M, Wasmund N, Bauwe H (2019) Cyanobacterium Nodularia spumigena strain CCY9414 accumulates polyphosphate under long-term P-limiting conditions. Aquat Microb Ecol. 82:267–276

Zimmer D, Panten K, Frank M, Springer A, Leinweber P (2019) Sulfur-Enriched Bone Char as Alternative P Fertilizer: Spectroscopic, Wet Chemical, and Yield Response Evaluation. Agriculture 9, 21

John DS, Aschenbach J, Krüger B, Sendler M, Weiss FU, Mayerle J, Lerch MM, Aghdassi AA (2019) Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin. J Biol Chem. 294(2):697-707. doi: 10.1074/jbc.RA118.004376

Pollmann S, Springer A, Rustgi S, von Wettstein D, Kang C, Reinbothe C, Reinbothe S (2019) Substrate channeling in oxylipin biosynthesis through a protein complex in the plastid envelope of Arabidopsis thaliana. Journal of Experimental Botany. 70(5):1483-1495

Abshagen K, Degenhardt B, Liebig M, Wendt A, Genz B, Schaeper U, Stumvoll M, Hofmann U, Frank M, Vollmar B, Klöting N (2018). Liver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration. Scientific reports 8(1):16858. doi:10.1038/s41598-018-35325-3

Jonitz-Heincke A, Tillmann J, Ostermann M, Springer A, Bader R, Hol PJ, Cimpan MR (2018) Label-Free Monitoring of Uptake and Toxicity of Endoprosthetic Wear Particles in Human Cell Cultures. International journal of molecular sciences 19(11):3486. doi:10.3390/ijms19113486

Kram W, Rebl H, Wyrwa R, Laube T, Zimpfer A, Maruschke M, Frank M, Vollmar B, Kundt G, Schnabelrauch M, Nebe B, Buchholz N, Hakenberg OW (2018) Paclitaxel-coated stents to prevent hyperplastic proliferation of ureteral tissue: from in vitro to in vivo. Urolithiasis. doi: 10.1007/s00240-018-1081-7

Mader F, Müller S, Krause L, Springer A, Kernig K, Protzel C, Porath K, Rackow S, Wittstock T, Frank M, Hakenberg OW, Köhling R, Kirschstein T (2018) Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility. Frontiers in physiology 9:753. doi:10.3389/fphys.2018.00753

Streckenbach F, Klose R, Langner S, Langner I, Frank M, Wree A, Neumann AM, Glass Ä, Stahnke T, Guthoff RF, Stachs O, Lindner T (2018) Ultrahigh-Field Quantitative MR Microscopy of the Chicken Eye In Vivo Throughout the In Ovo Period. Mol Imaging Biol. doi: 10.1007/s11307-018-1208-9

Engel N, Adamus A, Frank M, Kraft K, Kühn J, Müller P, Nebe B, Kasten A, Seitz G (2018) First evidence of SGPL1 expression in the cell membrane silencing the extracellular S1P siren in mammary epithelial cells. PloS One. 13(5). doi:10.1371/journal.pone.0196854

Fröck H, Milkereit B, Wiechmann P, Springer A, Sander M, Kessler O, Reich M (2018) Influence of Solution-Annealing Parameters on the Continuous Cooling Precipitation of Aluminum Alloy 6082. Metals 8(4):265. doi:10.3390/met8040265

Ebner L, Gläser A, Bräuer A, Witt M, Wree A, Rolfs A, Frank M, Vollmar B, Kuhla A (2018) Evaluation of Two Liver Treatment Strategies in a Mouse Model of Niemann-Pick-Disease Type C1.International journal of molecular sciences. 19(4):972. doi:10.3390/ijms19040972

Isenring J, Köhler J, Nakata M, Frank M, Jans C, Renault P, Danne C, Dramsi S, Kreikemeyer B, Oehmcke-Hecht S (2018). Streptococcus gallolyticus subsp. gallolyticus endocarditis isolate interferes with coagulation and activates the contact system. Virulence 9(1):248-261.

Ibad MF, Kosslick H, Tomm JW, Frank M, Schulz A (2017) Impact of thy crystallinity of mesoporus polymeric graphitic carbon nitride on the photocatalytic performance under UV and visible light. Microporous and Mesoporous Materials 254:136-145

Steinbauer J, Longwitz L, Frank M, Epping J, Kragl U, Werner T (2017) Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO2 and epoxides. Green Chem. 19:4435-4445.

Grambow E, Leppin C, Leppin K, Kundt G, Klar E, Frank M, Vollmar B (2017) The effects of hydrogen sulfide on platelet-leukocyte aggregation and microvascular thrombolysis. Platelets 28(5):509-517.

Buhr F, Lahroussi A, Springer A, Rustgi S, von Wettstein S, Reinbothe C, Reinbothe S (2017) NADPH:protochlorophyllide oxidoreductase B (PORB) action in Arabidopsis thaliana revisited through transgenic expression of engineered barley PORB mutant proteins. Plant Molecular Biology. 94 (1-2):45–59.

Markhoff J, Zietz C, Fabry C, Fulda G, Bader R (2017) Influence of analyzed lubricant volumes on the amount and characteristics of generated wear particles from three different types of polyethylene liner materials. J Biomed Mater Res B Appl Biomater. 106(3):1299-1306. doi: 10.1002/jbm.b.33944

Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A (2017) Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour. Growth Horm IGF Res. 33:1-8. PMID: 27919008

Trilck M, Peter F, Zheng C, Frank M, Dobrenis K, Mascher H, Rolfs A, Frech MJ (2017) Diversity of Glycosphingolipid GM2 and Cholesterol Accumulation in NPC1 Patient-Specific iPSC-Derived Neurons. Brain Res. 1657:52-61 PMID: 27923633

Peppel T, Seeburg D, Fulda G, Kraus M, Trommler U, Roland U, Wohlrab S (2017) Methods for trace oxygen removal from methane-rich-gas streams. Chemical Engineering Technology 40(1):153-161.

Wallis P, Wohlrab S, Kalevaru VN, Frank M, Martin A (2016) Impact of pore structure and morphology on catalyst performance of Vox/SBA-15 for selective methane oxidation. Catalysis Today 278:120-126

Nebe B, Moerke C, Staehlke S, Finke B, Schnabelrauch M, Anselme K, Helm CA, Frank M, Rebl H (2016) Complex cell physiology on topographically and chemically designed material surfaces. Materials Science Forum879:78-83

Engel N, Ali I, Adamus A, Frank M, Dad A, Ali S, Nebe B, Atif M, Ismail M, Langer P, Ahmad VU (2016) Antitumor evaluation of two selected Pakistani plant extracts on human bone and breast cancer cell lines. BMC Complement Altern Med 16:244. PMID: 27457235

Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP (2016) Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation. Sci. Rep 24(6):26562. PMID: 27217206

Witte K, Bodnar W, Mix T, Schell N, Fulda G, Woodcock TG, Burkel E (2016) A detailed study on the transition from the blocked to the superparamagnetic state of reduction-precipitated iron oxide nanoparticles. Journal of Magnetism and Magnetic Materials 403:103-113 

Springer A, Kang C, Rustgi S, von Wettstein D, Reinbothe C, Pollmann S, Reinbothe S (2016) Programmed chloroplast destruction during leaf senescence involves 13-lipoxygenase (13-LOX). Proc Natl Acad Sci U S A. 113(12):3383-8. doi: 10.1073/pnas.1525747113.

Ehrlich H, Motylenko M, Sundareshwar PV, Ereskovsky A, Zglobicka I, Noga T, Plocinski T, Tsurkan MV, Wyroba E, Suski S, Bilski H, Wysokowski M, Stöcker H, Makarova A, Vyalikh D, Walter J, Molodtsov SL, Bazhenov VV, Petrenko I, Langer E, Richter A, Niederschlag E, Pisarek M, Springer A, Gelinsky M, Rafaja D, Witkowski A, Meyer DC, Jesionowski T, Kurzydlowski KJ (2016) Multiphase Biomineralization: Enigmatic Invasive Siliceous Diatoms Produce Crystalline Calcite. Advanced Functional Materials 26:2503–2510

Hoffmann M, Kreft S, Georgi G, Fulda G, Pohl M-M, Seeburg D, Berger-Karin C, Kondratenko EV, Wohlrab S (2015) Improved catalytic methane combustion of Pd/CeO2 catalysts via porous glass integration. Applied Catalysis B: Environmental 179:313-320.

Schellhorn M, Haustein M, Frank M, Linnebacher M, Hinz B (2015) Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Oncotarget 6(36):39342-39356.

Desens W, Kohrt C, Frank M, Werner T (2015) Highly Efficient Polymer-Supported Catalytic System for the Valorization of Carbon Dioxide. Chem Sus Chem 8(22):3815-3822.

Orf I, Klähn S, Schwarz D, Frank M, Hess WR, Hagemann M, Kopka J (2015) Integrated Analysis of Engineered Carbon Limitation in a Quadruple CO2/HCO3- Uptake Mutant of Synechocystis sp. PCC 6803. Plant Physiol 169(3):1787-1806.

Timm S, Wittmiß M, Gamlien S, Ewald R, Florian A, Frank M, Wirtz M, Hell R, Fernie AR, Bauwe H (2015) Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana. Plant Cell 27(7):1968-1984.

Fazekas F, Enzinger C, Schmidt R, Grittner U, Giese AK, Hennerici MG, Huber R, Jungehulsing GJ, Kaps M, Kessler C, Martus P, Putaala J, Ropele S, Tanislav C, Tatlisumak T, Thijs V, von Sarnowski B, Norrving B, Rolfs A; SIFAP 1 Investigators (incl. Laue M, Jonas L) (2015) Brain magnetic resonance imaging findings fail to suspect Fabry disease in young patients with an acute cerebrovascular event. Stroke 46(6):1548-1553.

Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, Arnold SJ (2015) Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells. EMBO J. 2015 34(8):1078-1089.

Hoentsch M, Bussiahn R, Rebl H, Bergemann C, Eggert M, Frank M, von Woedtke T, Nebe B (2014) Persistent effectivity of gas plasma-treated, long time-stored liquid on epithelial cell adhesion capacity and membrane morphology. PLoS One 9(8):e104559.

Yan X, Ma L, Hovakimyan M, Lukas J, Wree A, Frank M, Guthoff R, Rolfs A, Witt M, Luo J (2014) Defects in the retina of Niemann-pick type C 1 mutant mice. BMC Neurosci. 15:126.

Behrend D, Warkentin M, Klüß D, Bader R, Kopp S, Frank M, Mittelmeier W (2014) [Failure analysis as basis for quality assurance strategies in implant technology]. Orthopäde. 43(6):555-60.

Schäd SG, Heitland P, Kühn-Velten WN, Gross GE, Jonas L (2013) Time-dependent decrement of dermal gadolinium deposits and significant improvement of skin symptoms in a patient with nephrogenic systemic fibrosis after temporary renal failure. J Cutan Pathol. 40(11):935-44

Grambow E, Mueller-Graf F, Delyagina E, Frank M, Kuhla A, Vollmar B (2013) Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice. Platelets. 25(3):166-74

Zietz C, Fabry C, Middelborg L, Fulda G, Mittelmeier W, Bader R (2013) Wear testing and particle characterisation of sequentially crosslinked polyethylene acetabular liners using different femoral head sizes. J Mater Sci Mater Med. 24(8):2057-65

Jentsch H, Mozaffari E, Jonas L (2013) Scanning electron microscopy of growing dental plaque: a quantitative study with different mouth rinses. Ultrastruct Pathol. 37(4):233-40

Weber H, Müller L, Jonas L, Schult C, Sparmann G, Schuff-Werner P (2013) Calpain mediates caspase-dependent apoptosis initiated by hydrogen peroxide in pancreatic acinar AR42J cells. Free Radic Res. 47(5):432-46

Laue M, Fulda G (2013) Rapid and reliable detection of bacterial endospores in environmental samples by diagnostic electron microscopy combined with X-ray microanalysis. J Microbiol Methods. 94(1):13-21

Labrenz M, Grote J, Mammitzsch K, Boschker HT, Laue M, Jost G, Glaubitz S, Jürgens K (2013) Sulfurimonas gotlandica sp. nov., a chemoautotrophic and psychrotolerant epsilonproteobacterium isolated from a pelagic redoxcline, and an emended description of the genus Sulfurimonas. Int J Syst Evol Microbiol. 63(Pt 11):4141-8

Fazekas F, Enzinger C, Schmidt R, Dichgans M, Gaertner B, Jungehulsing GJ, Hennerici MG, Heuschmann P, Holzhausen M, Kaps M, Kessler C, Martus P, Putaala J, Ropele S, Tanislav C, Tatlisumak T, Norrving B, Rolfs A; sifap1 Investigators (incl. Laue M, Jonas L) (2013). MRI in acute cerebral ischemia of the young: the Stroke in Young Fabry Patients (sifap1) Study. Neurology. 81(22):1914-21

Rolfs A, Fazekas F, Grittner U, Dichgans M, Martus P, Holzhausen M, Böttcher T, Heuschmann PU, Tatlisumak T, Tanislav C, Jungehulsing GJ, Giese AK, Putaala J, Huber R, Bodechtel U, Lichy C, Enzinger C, Schmidt R, Hennerici MG, Kaps M, Kessler C, Lackner K, Paschke E, Meyer W, Mascher H, Riess O, Kolodny E, Norrving B; Stroke in Young Fabry Patients (sifap) Investigators (incl. Laue M, Jonas L). (2013) Acute cerebrovascular disease in the young: the Stroke in Young Fabry Patients study. Stroke. 44(2):340-9